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Enuresis associated with sleep disordered breathing in children with sickle cell anemia

Gloria C Lehmann1, Teal R Bell, Fenella J Kirkham

  • 1Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.

The Journal of Urology
|August 23, 2012
PubMed

Insights

Sleep disordered breathing is linked to enuresis in children with sickle cell anemia. Early evaluation by a pulmonologist is recommended for children with enuresis.

Area of Science:

  • Pediatrics
  • Pulmonology
  • Genetics

Background:

  • Enuresis and sleep disordered breathing (SDB) are prevalent in pediatric sickle cell anemia (SCA).
  • The relationship between these conditions in SCA patients remains under-explored.

Purpose of the Study:

  • To investigate the association between enuresis and SDB in children with SCA.

Main Methods:

  • A multicenter prospective cohort study included 221 children with SCA.
  • Parental questionnaires assessed enuresis presence and severity.
  • Overnight polysomnography quantified SDB via obstructive apnea-hypopnea index (OAHI).
  • Logistic and ordinal regression models analyzed the association.

Main Results:

  • Enuresis was reported in 38.9% of participants.
  • An OAHI of ≥2/hour was significantly associated with enuresis (OR 2.19; p=0.03).
  • Enuresis severity correlated with SDB, particularly with ≥3% desaturation events (OR 3.23; p=0.001).

Conclusions:

  • SDB is significantly associated with enuresis in children with SCA.
  • Children with SCA presenting with enuresis warrant evaluation for SDB by a pulmonologist.
Abstract

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