Related Experiment Videos

Prevalence and association of microalbuminuria in essential hypertensive patients

Bibek Poudel1, Binod Kumar Yadav, Ashwini Kumar Nepal

  • 1Department of Biochemsitry, Manipal College of Medical Sciences, Pokhara, Nepal.

North American Journal of Medical Sciences
|August 23, 2012
PubMed
Abstract

Insights

Microalbuminuria is strongly associated with hypertension, indicating kidney damage. This urinary albumin creatinine ratio can help assess cardiovascular and renal disease risk in hypertensive patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • Microalbuminuria signifies early kidney damage in hypertension.
  • It predicts end-stage renal disease and cardiovascular disease.
  • Studying urinary albumin creatinine ratio is crucial for hypertensive patients.

Purpose of the Study:

  • To determine the prevalence of microalbuminuria in newly diagnosed essential hypertension.
  • To investigate the association between microalbuminuria and hypertension.

Main Methods:

  • 106 newly diagnosed essential hypertensive patients and 106 normotensive controls were enrolled.
  • Hypertension defined by Joint National Committee-VII criteria.
  • Microalbuminuria measured using U-Albumin (NycoCard) and adjusted for urine creatinine.

Main Results:

  • 51.88% of hypertensive cases and 13.2% of controls had microalbuminuria (OR 7.086, P<0.001).
  • Prevalence was significant in both male (46.67% vs 12.08%) and female (58.7% vs 14.58%) populations.
  • Strong association found between microalbuminuria and hypertension.

Conclusions:

  • Microalbuminuria is a useful marker for assessing cardiovascular and renal disease risk.
  • Findings highlight the importance of monitoring microalbuminuria in hypertensive individuals.
  • Early detection of microalbuminuria aids in risk management strategies.
Keywords:
Albumin creatinine ratioHypertensionMicroalbuminuriaNormotension

Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...