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Updated: May 19, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
11:02

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

Profiling antibody drug conjugate positional isomers: a system-of-equations approach

Lan N Le1, Jamie M R Moore, Jun Ouyang

  • 1Early Stage Pharmaceutical Development, Genentech, Inc, South San Francisco, California 94080, United States.

Analytical Chemistry
|August 24, 2012
PubMed
Summary

We developed a mathematical method to analyze antibody drug conjugates (ADCs), which deliver chemotherapy to cancer cells. This technique precisely maps drug locations on antibodies, revealing consistent conjugation patterns.

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