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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
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DHT-Induced lncRNA AC092718.4 Promotes Prostate Cancer Cell Proliferation via ceRNA Mechanism.

Lian Jin1,2, Shan Feng1,2, Wei-Jie Sun2

  • 1School of Life Sciences, Yunnan University, Kunming 650500, China.

Genes
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

This study identifies AC092718.4 as a novel oncogenic long non-coding RNA (lncRNA) in prostate cancer. Its upregulation by dihydrotestosterone (DHT) promotes tumor growth and progression by sponging miR-138-5p, offering potential therapeutic targets.

Keywords:
AC092718.4androgenceRNAlncRNAsprostate cancer

Related Experiment Videos

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Androgen receptor (AR) signaling drives prostate cancer progression.
  • Dihydrotestosterone (DHT) binding to AR activates transcription, including long non-coding RNAs (lncRNAs).
  • DHT-induced lncRNAs are implicated in prostate cancer pathogenesis.

Purpose of the Study:

  • Identify and characterize DHT-induced lncRNAs in prostate cancer.
  • Elucidate the role and mechanism of a specific lncRNA, AC092718.4, in prostate cancer.
  • Explore AC092718.4 as a potential diagnostic and therapeutic target.

Main Methods:

  • Transcriptome analysis of LNCaP cells treated with varying DHT concentrations.
  • Correlation analysis with TCGA prostate cancer data.
  • In vitro and in vivo experiments to assess AC092718.4 function and mechanism.
  • miRNA sponge activity investigation.

Main Results:

  • AC092718.4 expression is elevated in AR-positive prostate cancer tissues and correlates with Gleason score.
  • DHT upregulates AC092718.4 in a concentration-dependent manner.
  • AC092718.4 overexpression promotes cell proliferation and inhibits apoptosis; knockdown suppresses tumor growth.
  • AC092718.4 acts as a sponge for miR-138-5p, releasing oncogenes (FERMT2, RHOC, HIF1A) and driving cancer progression.

Conclusions:

  • AC092718.4 functions as an oncogenic factor in prostate cancer.
  • The AC092718.4/miR-138-5p/mRNA pathway promotes prostate cancer progression.
  • This pathway represents a promising target for prostate cancer diagnostics and therapeutics.