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Updated: May 19, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Atypical pituitary adenoma with neurocytic transformation
Fabio Rotondo1, Marie Christine F Bernardo, Bernd W Scheithauer
1*Department of Laboratory Medicine and Pathology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada †Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN ‡Departments of Pathology §Neurosurgery, Methodist Children's Hospital of South Texas, San Antonio, TX ∥Department of Pathology, Acibadem Medical Center, Istanbul, Turkey.
Abstract:
Here, we report an example of an atypical prolactin-producing pituitary adenoma showing clear morphologic and immunohistochemical evidence of neurocytic transformation. Its features support the concept that neoplastic neuroendocrine cells, in this case adenohypophyseal cells, are capable of neuronal differentiation and broaden the morphologic spectrum of such rare tumors. Our findings have implications with respect to the nosology of neuronal tumors of the adenohypophysis.
