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Updated: May 19, 2026

Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure
Published on: March 21, 2017
Plasma biomarkers for Alzheimer's disease: much needed but tough to find
Chantal Bazenet1, Simon Lovestone
1King's College London, Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK.
Abstract:
Alzheimer's disease is a complex age-dependent neurodegenerative disease where definitive diagnosis is only possible after autopsy and where there is a long prodromal or preclinical phase. Biomarkers for both early diagnosis and prediction of disease progression are needed and extensive efforts to discover them have been undertaken. In this article, we have attempted to summarize the findings of current studies using proteomics and metabolomics approaches. We are also discussing how the use of emerging technologies and better study designs can support the identification of the much-needed Alzheimer's disease plasma biomarkers.
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