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General anesthetics and β-amyloid protein

Zhongcong Xie1, Zhipeng Xu

  • 1Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 4310, Charlestown, MA 02129, United States.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|August 25, 2012
PubMed
Summary

Common anesthetics may increase beta-amyloid (Aβ) accumulation, a hallmark of Alzheimer's disease (AD). Further research is needed to understand anesthetic neurotoxicity and its link to AD development.

Keywords:
99-residue membrane-associated C-terminus fragmentADAICDAPH-1APPAPP-C83APP-C99APP-CTFAPP-c-terminal fragmentATPAdenosine-5'-triphosphateAlzheimer's diseaseAβBACEBACE cleavage of APPCADDAPTGeneral anestheticsIDEInsulin degrading enzymeN-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl esterNeurotoxicityPEN-2TNF-αWTZ-VADamyloid precursor proteinanterior pharynx-defective 1carbobenzoxy-valyl -alanyl-aspartyl-[Omethyl]- fluromethylketonecarboxyl-terminus fragment of 83 amino acidscoronary artery diseasepresenilin enhancer 2tumor necrosis factor-αwild-typeα-APPsα-secretase cleavage of APPβ-APPsβ-Amyloid proteinβ-amyloid precursor protein intracellular domainβ-amyloid proteinβ-site APP-cleaving enzyme

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