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Related Experiment Video

Updated: May 19, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

The split hand sign.

Rajesh Benny¹, Kishore Shetty

¹Department of Neurology, Fortis and MGM Hospitals, Mumbai, Maharashtra, India.

Annals of Indian Academy of Neurology

|August 25, 2012

Summary

This summary is machine-generated.

Amyotrophic Lateral Sclerosis (ALS) causes muscle wasting and upper motor neuron signs. The split hand sign, a specific muscle weakness pattern, aids in bedside diagnosis of ALS.

Keywords:

Amyotrophic lateral sclerosis dissociated intrinsic hand muscle weakness split hand sign

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Area of Science:

Neurology
Clinical Neuroscience
Motor Neuron Diseases

Background:

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease.
It affects motor neurons, leading to muscle weakness and atrophy.
Asymmetric muscle wasting is a common clinical presentation.

Purpose of the Study:

To highlight the diagnostic utility of the split hand sign in Amyotrophic Lateral Sclerosis (ALS).
To describe the specific muscle involvement characteristic of the split hand sign in ALS patients.

Main Methods:

Clinical observation and assessment of muscle strength in patients with suspected or confirmed ALS.
Evaluation of the split hand sign, focusing on the differential wasting between thenar and hypothenar muscles.

Main Results:

The split hand sign, characterized by disproportionate wasting of thenar muscles compared to hypothenar muscles, was identified.
This dissociation of muscle weakness is a key indicator observed in ALS patients.

Conclusions:

The split hand sign is a valuable and practical clinical sign for the bedside diagnosis of Amyotrophic Lateral Sclerosis (ALS).
Recognizing this specific pattern of hand muscle weakness can aid clinicians in early ALS detection.