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Related Experiment Videos

Ultrastructural basis for different pertechnetate uptake patterns by various human brain tumours.

P Bar-Sella, D Front, R Hardoff

    Journal of Neurology, Neurosurgery, and Psychiatry
    |October 1, 1979
    PubMed
    Summary

    Intercellular tight junctions, not fenestrations, influence brain tumor permeability to pertechnetate (a radionuclide). This finding impacts understanding of radionuclide uptake in brain tumors.

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    Area of Science:

    • Neuroscience
    • Oncology
    • Radiology

    Background:

    • Brain tumor characteristics influence radionuclide uptake.
    • Understanding endothelial wall properties is key to brain tumor imaging.

    Purpose of the Study:

    • To correlate pertechnetate uptake patterns with brain tumor endothelial wall ultrastructure.
    • To identify factors affecting radionuclide permeability in human brain tumors.

    Main Methods:

    • Examined 14 human brain tumors.
    • Correlated pertechnetate uptake with endothelial ultrastructural properties.
    • Analyzed intercellular junctions and fenestrations.

    Main Results:

    • Reduced pertechnetate uptake correlated with the presence of intercellular tight junctions.

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  • Increased pertechnetate uptake correlated with the absence of intercellular tight junctions.
  • Fenestrations were present in some tumors with increased uptake, but absent in others.

    • Conclusions:

    • Intercellular tight junctions, rather than fenestrations, are the primary determinant of brain tumor permeability to pertechnetate.
    • This suggests a mechanism for differential radionuclide distribution in brain tumors.