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Updated: May 19, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Biomarkers for eosinophilic esophagitis: a review
Neeti Bhardwaj1, Gisoo Ghaffari
1Division of Pulmonary, Allergy and Critical Care Medicine, Pennsylvania State University College of Medicine, Hershey, USA. nbhardwaj@hmc.psu.edu
Summary
Eosinophilic esophagitis (EoE) biomarkers like eotaxin-3 and IL-13 show promise for diagnosis and monitoring disease activity. Further research is needed to validate these and other potential markers.
Area of Science:
- Gastroenterology
- Immunology
- Molecular Biology
Background:
- Eosinophilic esophagitis (EoE) has a complex pathophysiology with several potential biomarkers.
- These biomarkers could aid in diagnosis, assessing treatment response, and monitoring disease recurrence.
Purpose of the Study:
- To conduct a literature review on various biomarkers for EoE.
- To evaluate the correlation of these biomarkers with disease activity and treatment response.
Main Methods:
- A comprehensive literature search was performed using PubMed and OVID.
- 26 studies published between 2006 and 2012 investigating EoE biomarkers were selected.
Main Results:
- Investigated biomarkers include eotaxins, interleukins (IL-5, IL-13), eosinophil-derived neurotoxin, mast cell markers, and microRNAs.
- Eotaxin-3, IL-5, and IL-13 mRNA expression in esophageal tissue correlated positively with EoE disease activity.
- Eotaxin-3 mRNA staining demonstrated 89% sensitivity for EoE diagnosis; microRNA signatures also showed potential.
Conclusions:
- Eotaxin-3 and IL-13 are the most promising biomarkers for EoE due to their sensitivity and correlation with disease activity.
- Future research should focus on longitudinal studies, establishing normal values, and validating methodologies for EoE biomarkers.
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