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Targeted DNA Methylation Analysis by Next-generation Sequencing
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Targeted DNA Methylation Analysis by Next-generation Sequencing

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Single-molecule, genome-scale analyses of DNA modifications: exposing the epigenome with next-generation technologies

Karina Zillner1, Attila Németh

  • 1Biochemistry Center Regensburg, University of Regensburg, Universitätsstrasse 31, D-93053, Regensburg, Germany.

Epigenomics
|August 28, 2012
PubMed

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Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...