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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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Novel diphenylmethyl-derived amide protecting group for efficient liquid-phase peptide synthesis: AJIPHASE

Daisuke Takahashi1, Tatsuya Yano, Tatsuya Fukui

  • 1Research Institute for Bioscience Products and Fine Chemicals, AJINOMOTO Co., Inc., 1730 Hinaga Yokkaichi Mie 510-0885, Japan. daisuke_takahashi@ajinomoto.com

Organic Letters
|August 28, 2012
PubMed

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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
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Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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