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Related Experiment Video

Updated: May 19, 2026

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

Facilitated/pharmaco-invasive approaches in STEMI.

Davide Capodanno¹, George Dangas

¹Ferrarotto Hospital, University of Catania, Catania, Italy.

Current Cardiology Reviews

|August 28, 2012

Summary

This summary is machine-generated.

Primary percutaneous coronary intervention (PCI) is best for ST-elevation myocardial infarction (STEMI) when timely. Pharmacoinvasive recanalization may be an alternative for STEMI patients in centers lacking PCI facilities.

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Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

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Published on: June 20, 2025

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Last Updated: May 19, 2026

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

Area of Science:

Cardiology
Interventional Cardiology
Emergency Medicine

Background:

Primary percutaneous coronary intervention (PCI) is the gold standard for ST-elevation myocardial infarction (STEMI) reperfusion.
Logistical challenges and lack of PCI facilities can delay treatment, limiting primary PCI effectiveness.
Facilitated PCI, involving pretreatment before PCI, has not shown superiority over primary PCI.

Purpose of the Study:

To evaluate the role of pharmacoinvasive recanalization as an alternative reperfusion strategy for STEMI patients.
To assess the feasibility and potential benefits of early pharmacological reperfusion followed by delayed PCI.

Main Methods:

Review of current data on primary PCI, facilitated PCI, and pharmacoinvasive recanalization strategies.
Analysis of treatment outcomes in STEMI patients based on reperfusion method and facility availability.

Main Results:

Primary PCI is optimal when performed promptly by skilled operators.
Facilitated PCI does not offer advantages over primary PCI.
Pharmacoinvasive recanalization shows promise for STEMI patients in centers without immediate PCI capabilities.

Conclusions:

Pharmacoinvasive recanalization is a viable option for STEMI patients when timely primary PCI is not feasible.
This strategy allows for early reperfusion and subsequent definitive treatment, improving outcomes in resource-limited settings.