Related Experiment Video
Updated: May 19, 2026

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
Published on: June 25, 2017
The consequences of enhanced cell-autonomous glucose metabolism
1Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA. Locasale@cornell.edu
Abstract:
The intake and metabolism of carbohydrates for the generation of energy and biomass is evolutionarily conserved, down to the most primitive of cells. Although a basal rate of glucose metabolism occurs in all cells, the processing rates of glucose can become dramatically enhanced when cells acquire malignant properties, or remain undifferentiated. This article investigates the consequences of how increased glucose metabolism affects cellular physiology by altering the physicochemical properties of the whole metabolic network. As a result, enhanced lactate production in the presence of oxygen (the Warburg effect) is required, and metabolism is consequently reconfigured, through multiple mechanisms, to confer numerous physiological and possibly regulatory properties to cells.
Related Concept Videos
Type II Diabetes II: Pathophysiology
Hyperglycemia
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
