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Updated: May 19, 2026
11:12
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
[Apathy and deep brain stimulation in Parkinson's disease]
1Service de psychiatrie et de psychologie médicale, centre hospitalier universitaire Pontchaillou, Rennes, France. clement.lozachmeur@chu-rennes.fr
Revue Neurologique
|August 28, 2012
Summary
Parkinson's disease patients may develop apathy after subthalamic nucleus deep brain stimulation. Careful patient selection is crucial to mitigate this risk and preserve quality of life.
Area of Science:
- Neurology
- Neurosurgery
- Psychiatry
Context:
- Apathy affects up to 42% of Parkinson's disease patients, significantly impacting quality of life and potentially predicting cognitive decline.
- Deep brain stimulation (DBS) is a common treatment for Parkinson's disease, but certain targets may induce apathy.
Purpose:
- To explore the relationship between subthalamic nucleus deep brain stimulation and apathy in Parkinson's disease patients.
- To emphasize the need for careful patient selection and monitoring for apathy in DBS therapy.
Summary:
- Apathy, defined as diminished motivation unrelated to consciousness, cognition, or distress, is prevalent in Parkinson's disease.
- Subthalamic nucleus deep brain stimulation, unlike thalamic or pallidal stimulation, has been associated with inducing apathy.
- This finding necessitates a cautious approach to operability criteria and improved identification of at-risk individuals.
Impact:
- Highlights the importance of considering apathy when evaluating patients for subthalamic nucleus DBS.
- Suggests a need for refined screening protocols to identify Parkinson's disease patients at higher risk for apathy post-stimulation.
- Underscores the balance between the efficacy of DBS and potential neuropsychiatric side effects.
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