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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...

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Updated: May 19, 2026

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
10:57

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

DNA damage, NF-κB and accelerated aging.

David G Le Couteur1, David J Handelsman

  • 1ANZAC Medical Research Institute, Sydney 2139, Australia. david.lecouteur@sydney.edu.au

Asian Journal of Andrology
|August 28, 2012
PubMed
Summary
This summary is machine-generated.

Cellular aging mechanisms remain unclear, but DNA damage is a key factor. Altered transcription factor NF-κB (nuclear factor kappa B) activity mediates this, suggesting NF-κB inhibition could delay aging.

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Last Updated: May 19, 2026

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Published on: January 12, 2020

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Published on: August 21, 2021

Area of Science:

  • Gerontology
  • Molecular Biology
  • Genetics

Background:

  • Aging is a primary risk factor for numerous diseases and disabilities.
  • The precise cellular mechanisms driving the aging process are not fully understood.
  • Research into aging mechanisms is crucial for developing interventions against age-related decline.

Discussion:

  • Studies using transgenic mice with modified ERCC1 (a DNA repair enzyme) indicate DNA damage is a significant contributor to aging.
  • The transcription factor NF-κB (nuclear factor kappa B) plays a crucial role in mediating the aging effects of DNA damage.
  • Understanding the interplay between DNA repair, DNA damage, and NF-κB signaling is key to aging research.

Key Insights:

  • DNA damage is identified as a primary mechanism underlying the aging process.
  • The activity of NF-κB (nuclear factor kappa B) is a critical mediator linking DNA damage to aging.
  • Targeting NF-κB may offer a therapeutic strategy for delaying aging.

Outlook:

  • Further research into NF-κB inhibition could lead to novel anti-aging therapies.
  • Investigating the role of DNA repair enzymes like ERCC1 in aging may reveal new therapeutic targets.
  • This study provides a foundation for developing interventions to promote healthy aging and reduce age-related diseases.