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Updated: May 19, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

Correlation of von Willebrand factor gene polymorphism and coronary heart disease

Ai-Guo Xu1, Rong-Mei Xu, Chang-Qing Lu

  • 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China. zhengxuag@126.com

Molecular Medicine Reports
|August 28, 2012
PubMed

Insights

Von Willebrand factor (vWF) gene polymorphisms at site A1381T were not linked to coronary heart disease. However, plasma vWF levels were influenced by vWF gene variants, blood type, and coronary heart disease presence.

Area of Science:

  • Cardiovascular Genetics
  • Hematology

Background:

  • Von Willebrand factor (vWF) plays a crucial role in hemostasis and its association with cardiovascular diseases is an area of ongoing research.
  • Genetic variations in the vWF gene may influence plasma vWF levels and impact disease risk.

Purpose of the Study:

  • To investigate the association between vWF gene polymorphisms at site A1381T and coronary heart disease (CHD).
  • To examine the correlation of plasma vWF levels with vWF gene polymorphisms at site A1381T, blood type, and CHD.

Main Methods:

  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype the vWF gene at site A1381T in 110 CHD patients and 110 controls.
  • Plasma vWF levels were quantified using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • Plasma vWF levels were significantly higher in the CHD group compared to the control group.
  • The AG genotype at vWF site A1381T was associated with higher plasma vWF levels in CHD patients.
  • Blood type O individuals had lower plasma vWF levels compared to other blood types, particularly in the control group.
  • All blood types exhibited higher plasma vWF levels in the CHD group than in the control group.

Conclusions:

  • vWF gene polymorphisms at site A1381T are not directly associated with coronary heart disease.
  • Plasma vWF levels are significantly influenced by vWF gene polymorphisms at site A1381T, ABO blood type, and the presence of coronary heart disease.

Keywords:
von Willebrand factorpolymorphismcoronary heart diseaseblood type

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