Acetylcholine for male LUTS
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Updated: May 19, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
Steven J Weissbart1, Bilal Chughtai, Dean Elterman
1James Buchanan Brady Department of Urology, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Abstract:
In this review, we present the evidence on the safety and efficacy of anticholinergic therapy for men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and emphasize the data published over the past year. This review discusses two classes of medications whose mechanism of action attenuates the effect of acetylcholine on the LUT: anticholinergics and botulinum toxin. We review the randomized controlled trials that investigate the efficacy and side effects of anticholinergics when used in men with LUTS secondary to BPH. We emphasize new studies and developments that have been made in the past year.
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