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Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
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Cholinergic Neurons: Neurotransmission01:23

Cholinergic Neurons: Neurotransmission

Cholinergic neurotransmission involves the synthesis and the release of acetylcholine (ACh) in order to transmit nerve impulses across the synapse. The process begins with the synthesis of acetyl CoA, a precursor for ACh, from ATP, acetate, and coenzyme A in the mitochondria. Choline, another vital precursor, is transported inside the neuron through choline transporters, including high-affinity choline transporter CHT1, low-affinity choline transporter CTL1, and lower-affinity choline...
Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren syndrome.
Indirect-Acting Cholinergic Agonists: Pharmacological Actions01:30

Indirect-Acting Cholinergic Agonists: Pharmacological Actions

Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Direct-Acting Cholinergic Agonists: Pharmacological Actions00:59

Direct-Acting Cholinergic Agonists: Pharmacological Actions

Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
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Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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Related Experiment Video

Updated: May 19, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Acetylcholine for male LUTS.

Steven J Weissbart1, Bilal Chughtai, Dean Elterman

  • 1James Buchanan Brady Department of Urology, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

Current Urology Reports
|August 28, 2012
PubMed
Summary
This summary is machine-generated.

Anticholinergic medications effectively treat lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Recent studies confirm their safety and efficacy, offering valuable treatment options.

Related Experiment Videos

Last Updated: May 19, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Area of Science:

  • Urology
  • Pharmacology

Background:

  • Lower urinary tract symptoms (LUTS) significantly impact men with benign prostatic hyperplasia (BPH).
  • Acetylcholine plays a role in lower urinary tract (LUT) function, making its modulation a therapeutic target.

Purpose of the Study:

  • To review the current evidence on the safety and efficacy of anticholinergic therapy for LUTS in men with BPH.
  • To highlight recent advancements and data published within the past year regarding these treatments.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs).
  • Analysis of studies investigating anticholinergics and botulinum toxin for LUTS secondary to BPH.
  • Focus on efficacy, side effects, and recent developments.

Main Results:

  • Anticholinergic therapy demonstrates significant efficacy in managing LUTS associated with BPH.
  • The safety profile of anticholinergics in this patient population is well-established.
  • Recent data reinforce the established benefits and explore potential refinements in treatment.

Conclusions:

  • Anticholinergic agents are a safe and effective treatment option for men experiencing LUTS due to BPH.
  • Ongoing research continues to refine the understanding and application of these therapies.