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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
The GlycomeAtlas tool for visualizing and querying glycome data.
Yoshitsugu Konishi1, Kiyoko F Aoki-Kinoshita
1Department of Bioinformatics, Faculty of Engineering, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo 192-8577, Japan.
GlycomeAtlas is a new tool for visualizing and querying glycan structures. It allows researchers to analyze data from the Consortium for Functional Glycomics (CFG) and their own glycomic datasets.
Area of Science:
- Glycomics
- Bioinformatics
- Mass Spectrometry
Background:
- Recent advancements in glycomics technologies have generated vast amounts of glycan structure data.
- Glycan profiling via mass spectrometry (MS) and tandem MS produces large datasets requiring analysis.
- Existing resources like the Consortium for Functional Glycomics (CFG) offer valuable glycan data but have limitations in searching and comparative analysis.
Purpose of the Study:
- To develop an accessible tool for visualizing and querying glycan profiling data.
- To enable researchers to better utilize mass spectrometry-derived glycome data.
- To facilitate the search for specific glycans and identification of commonalities across different tissues and organisms.
Main Methods:
- Development of a user-friendly tool named GlycomeAtlas.
- Pre-loading GlycomeAtlas with glycan profiling data from the Consortium for Functional Glycomics (CFG).
- Enabling users to upload and analyze their own local glycan profiling data.
Main Results:
- GlycomeAtlas provides visualization and query capabilities for glycome data.
- The tool is pre-populated with CFG data, offering immediate access to a large glycan database.
- Users can integrate and analyze their own experimental glycan profiling data within the GlycomeAtlas environment.
Conclusions:
- GlycomeAtlas enhances the accessibility and utility of glycomic datasets.
- The tool supports both public and private glycan data analysis, promoting broader research applications.
- GlycomeAtlas serves as a valuable resource for researchers in glycomics and related fields.
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