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Total synthesis of epiberberine
Zi-Ming Lu1, Jun-Qing Liang, Hong-Tao Wang
1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Journal of Asian Natural Products Research
|August 29, 2012
Abstract:
Epiberberine, a natural bioactive protoberberine alkaloid, was totally synthesized in short, convenient and low-cost, four-step reactions including cyclization, condensation, reduction, and ring-closing, with an overall yield of 26.1%.
