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Updated: May 19, 2026

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
Bis(perfluoroalkyl) phosphino-oxazoline: a modular, stable, strongly π-accepting ligand for asymmetric catalysis
Zongjian Hu1, Yuguang Li, Kai Liu
1Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
Abstract:
A new class of stable, strongly π-accepting and modular bis(perfluoroalkyl)-phosphine-oxazoline ligands (FOX) as CO mimics was prepared. It was demonstrated that these ligands, when coordinated to palladium catalysts, promote the asymmetric alkylation of monosubstituted allyl substrates with excellent regio- and enantioselectivity. Solid and solution structure analysis of the FOX-ligated Pd-allyl intermediate reveals that the combination of relative steric and strong trans influences presented by the P(CF(3))(2) moiety gave rise to the excellent selectivity.
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