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Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

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Sensitive refractive index detection using a broad-band optical ring resonator.

Thomas C Oates1, Lloyd W Burgess

  • 1Department of Chemistry, University of Washington, Seattle, 98195, United States.

Analytical Chemistry
|August 29, 2012
PubMed
Summary

This study introduces broad-band operation for liquid-core optical ring resonators (LCORR) enabling sensitive refractive index detection. This method uses multiple resonance peaks for enhanced analysis, achieving detection limits of 10(-6) RIU.

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Area of Science:

  • Analytical Chemistry
  • Optical Sensing
  • Spectroscopy

Background:

  • Optical ring resonators offer sensitive detection of various analytes in small volumes.
  • Conventional methods rely on single resonant wavelengths and high-quality resonators.
  • Liquid-core optical ring resonators (LCORR) present a versatile platform for sensing applications.

Purpose of the Study:

  • To investigate broad-band operation as an alternative refractive index detection method in LCORR.
  • To demonstrate enhanced detection capabilities using multiple resonance peaks from a modest quality device.
  • To explore the feasibility of LCORR for surface analyte and biomolecule detection.

Main Methods:

  • Utilized a liquid-core (capillary-based) optical ring resonator design.
  • Employed broad-band operation analyzing over 40 simultaneous resonance peaks.
  • Applied Fourier transform deconvolution and chemometrics (partial least-squares modeling) for data analysis.
  • Investigated isopropyl alcohol/water mixtures and bovine serum albumin (BSA) adsorption.

Main Results:

  • Achieved refractive index detection limits on the order of 10(-6) RIU, comparable to existing devices.
  • Demonstrated impressive results exceeding single-mode predictions using multiple-mode analysis.
  • Showcased the potential for surface detectability and biomolecule analysis with LCORR.
  • Integrated inexpensive LED light sources and UV-vis spectrometers, enabling simultaneous absorbance measurements.

Conclusions:

  • Broad-band operation in LCORR provides a robust and sensitive approach for refractive index detection.
  • Multi-mode analysis overcomes limitations of resonator quality, enhancing analytical performance.
  • LCORR technology is suitable for diverse applications, including environmental monitoring and biomolecule sensing.