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Chronic granulocytic leukaemia presenting with mandibular mass
O P Kalra1, N Kalra, H K Aggarwal
1Department of Medicine, Medical College Hospital, Rohtak, Haryana.
Summary
A rare case of chronic granulocytic leukemia with extramedullary tumors in the mandible showed significant improvement. Combined systemic chemotherapy and local irradiation effectively reduced the mandibular mass, offering a potential treatment approach.
Area of Science:
- Hematology
- Oncology
- Oral and Maxillofacial Surgery
Background:
- Chronic granulocytic leukemia (CGL), now known as chronic myeloid leukemia (CML), is a myeloproliferative neoplasm.
- Extramedullary disease in CML can occur in various sites, posing diagnostic and therapeutic challenges.
- The mandible is an uncommon site for extramedullary CML deposits.
Observation:
- A patient presented with extramedullary CML deposits specifically involving the mandible.
- The mandibular mass caused significant local symptoms and complications.
- Standard diagnostic workup confirmed the CML infiltration of the mandibular bone and soft tissues.
Findings:
- A combination of systemic chemotherapy and localized radiation therapy was administered.
- The treatment regimen led to a notable regression of the mandibular mass.
- No significant adverse events were reported during the treatment course.
Implications:
- This case highlights the possibility of extramedullary CML in the mandible.
- Combined modality treatment (chemotherapy and irradiation) can be effective in managing such rare presentations.
- Further research is warranted to establish optimal treatment guidelines for extramedullary CML deposits in unusual locations.