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Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

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Related Experiment Video

Updated: May 19, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Imaging the myocardial microcirculation post-myocardial infarction.

Steven K White1, Derek J Hausenloy, James C Moon

  • 1The Heart Hospital, London, UK. steven.white@ucl.ac.uk

Current Heart Failure Reports
|August 29, 2012
PubMed
Summary

Acute myocardial infarction (AMI) reperfusion can cause microvascular injury, leading to the

Area of Science:

  • Cardiovascular Medicine
  • Cardiac Physiology
  • Medical Imaging

Background:

  • The myocardial microcirculation is crucial for cardiac function and homeostasis.
  • Microvascular dysfunction is linked to chronic heart disease and increased risk.
  • Acute myocardial infarction (AMI) management focuses on epicardial artery reperfusion, potentially neglecting microcirculatory damage.

Purpose of the Study:

  • To highlight the profound impact of microvascular injury following AMI.
  • To emphasize the 'no-reflow' phenomenon and its components: microvascular obstruction (MVO) and intramyocardial hemorrhage.
  • To underscore the role of advanced imaging in assessing MVO and its consequences.

Main Methods:

  • Review of current understanding of myocardial microcirculation in AMI.

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  • Discussion of the 'no-reflow' phenomenon and its pathological basis.
  • Highlighting the utility of myocardial contrast echocardiography and cardiac magnetic resonance imaging in evaluating MVO.

    • Main Results:

    • The 'no-reflow' phenomenon affects up to 40% of successfully reperfused ST-elevation AMI (STEMI) patients.
    • Microvascular obstruction (MVO) and intramyocardial hemorrhage are severe manifestations of microvessel injury.
    • MVO is a primary determinant of adverse left ventricular (LV) remodeling, dysfunction, heart failure, and mortality.

    Conclusions:

    • Current AMI management strategies may inadvertently cause significant microcirculatory damage.
    • Myocardial contrast echocardiography and cardiac MRI are essential tools for quantifying MVO.
    • Future research should focus on preserving microvascular function during AMI treatment.