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Updated: May 19, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Total syntheses of amphidinolides B, G, and H
Akihiro Hara1, Ryo Morimoto, Yuki Iwasaki
1Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.
Abstract:
Not one, not two, but three: Total syntheses of amphidinolides B, G, and H, which exhibit strong, nanogram-scale cytotoxicity against various tumor cell lines, have been executed. The synthetic strategy relied on implementation of a diene construction protocol and a diastereoselective aldol process. The 26- and 27-membered macrocyclic lactone rings were efficiently constructed by using ring-closing metathesis (RCM).
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