Related Experiment Video

Updated: Aug 14, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Drug targeting in cancer chemotherapy: a clinical perspective

P K Gupta1

  • 1College of Pharmacy, University of Kentucky, Lexington 40536-0082.

Journal of Pharmaceutical Sciences
|November 1, 1990
PubMed

Insights

Targeted drug delivery aims to concentrate medications in specific body tissues, enhancing cancer chemotherapy effectiveness. This review explores current research and clinical applications for carcinoma management.

Area of Science:

  • Pharmacology
  • Oncology
  • Biomedical Engineering

Background:

  • Drug targeting optimizes medication distribution to specific tissues at cellular or subcellular levels.
  • Conventional chemotherapy faces challenges with systemic toxicity and limited efficacy.
  • Targeted drug delivery strategies offer a promising approach to overcome these limitations.

Purpose of the Study:

  • To review the current research status in targeted drug delivery.
  • To emphasize the application of targeted drug delivery in managing carcinomas.
  • To provide an update on advancements in clinical applications.

Main Methods:

  • Literature review of existing research on drug targeting strategies.
  • Analysis of studies focusing on targeted drug delivery in cancer chemotherapy.
  • Evaluation of clinical applications for carcinoma treatment.

Main Results:

  • Various strategies have been developed for drug targeting.
  • Several targeted approaches have shown promise in clinical trials for cancer chemotherapy.
  • Targeted drug delivery is increasingly applied in the clinical management of carcinomas.

Conclusions:

  • Drug targeting is a key strategy for improving therapeutic outcomes in cancer treatment.
  • Continued research in targeted drug delivery is crucial for advancing carcinoma management.
  • Clinical application of targeted drug delivery holds significant potential for personalized cancer therapy.

More Related Videos

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

Screening Ion Channels in Cancer Cells06:19

Screening Ion Channels in Cancer Cells

Published on: June 16, 2023

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...