Related Experiment Video
Updated: May 19, 2026

Minimally-invasive Technique for Injection into Rat Optic Nerve
Published on: May 19, 2015
Current options for the treatment of optic neuritis
John H Pula1, Christopher J Macdonald
1Division of Neuro-ophthalmology, University of Illinois College of Medicine at Peoria, Peoria.
Abstract:
Optic neuritis can be defined as typical (associated with multiple sclerosis, improving independent of steroid treatment), or atypical (not associated with multiple sclerosis, steroid-dependent improvement). Causes of atypical optic neuritis include connective tissue diseases (eg, lupus), vasculitis, sarcoidosis, or neuromyelitis optica. In this manuscript, updated treatment options for both typical and atypical optic neuritis are reviewed. Conventional treatments, such as corticosteroids, therapeutic plasma exchange, and intravenous immunoglobulin therapy are all discussed with commentary regarding evidence-based outcomes. Less commonly used treatments and novel purported therapies for optic neuritis are also reviewed. Special scenarios in the treatment of optic neuritis - pediatric optic neuritis, acute demyelinating encephalomyelitis, and optic neuritis occurring during pregnancy - are specifically examined.
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