Related Experiment Video
Updated: May 19, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Aspirin sensitivity and chronic rhinosinusitis with polyps: a fatal combination
Hendrik Graefe1, Christina Roebke, Dirk Schäfer
1Departments of Otorhinolaryngology, Head and Neck Surgery, and Plastic Surgery, Asklepios Medical School, Lohmuehlenstraß 5, 20099 Hamburg, Germany.
Abstract:
Aspirin-exacerbated respiratory disease (AERD) refers to aspirin sensitivity, chronic rhinosinusitis (CRS), nasal polyposis, asthma, eosinophil inflammation in the upper and lower airways, urticaria, angioedema, and anaphylaxis following the ingestion of NSAIDs. Epidemiologic and pathophysiological links between these diseases are established. The precise pathogenesis remains less defined, even though there is some progress in the understanding of several molecular mechanisms. Nevertheless, these combinations of diseases in patients classified by AERD constitute a fatal combination and may be difficult to treat with standard medical and surgical interventions. This paper reviews in brief the epidemiology, clinical features, diagnosis, molecular pathogenesis, and specific therapies of patients classified by AERD and postulates future attempts to gain new insights into this disease.
Related Concept Videos
Allergic Reactions
Asthma I: Introduction
Drug toxicity: Drug–Drug Interaction
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Asthma-III: Symptoms and Complications
Classification of Asthma
