[CETP gene TaqIB polymorphism and plasma lipids in patients with overweight and obesity]

Ongoing research shows an increase in mortality in patients with low levels of serum cholesterol, which is caused by decreasing the fraction of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein (LDL-C).

The aim of our study was to assess the relationship between the CETP gene TaqI polymorphism and concentrations of selected parameters of lipid metabolism in patients with overweight and obesity.

The study involved 73 people aged 24-68 years. Android obesity was found in 90.4% of women, including 66.7% in the HDL-C levels above 50 mg/dL.

Most of abdominal obesity was the B1B2 heterozygotes (38.1%). Abdominal obesity was present in 48.4% of men, including 25.8% in B1B2 heterozygotes and in 67.7% of HDL > 40 mg/dl. It was found statistically insignificant higher levels of TG, TC, LDL-C, the percentage of fat mass (% FM) in patients with genotype B2B2 compared to those with genotype B1B1 and B1B2. In women, higher levels of TC, LDL-C and HDL-C were found in the presence of B1B2 genotype, whereas a higher concentration of all lipid fractions studied showed the men with the B2B2 genotype, who also had the highest % FM.

The results indicate that in obese men Tag1B polymorphism may be an independent factor influencing HDL-cholesterol.