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Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
An institution-specific analysis of ACL reconstruction failure
Rachel M Frank1, Kevin C McGill, Brian J Cole
1Division of Sports Medicine, Department of Orthopedics, Rush University Medical Center, Chicago, Illinois 60612, USA.
The Journal of Knee Surgery
|August 30, 2012
Summary
Traumatic re-injury, not surgical error, is the most common cause of anterior cruciate ligament reconstruction (ACLR) failure. Revision ACLR generally yields good to excellent outcomes, indicating successful patient recovery after re-operation.
Area of Science:
- Orthopedic Surgery
- Sports Medicine
- Biomechanical Engineering
Background:
- Anterior cruciate ligament reconstruction (ACLR) is a common surgical procedure.
- Understanding failure mechanisms is crucial for improving outcomes.
- Modern ACLR techniques aim for anatomic reconstruction and secure fixation.
Purpose of the Study:
- Determine common causes of failed ACLR using modern techniques.
- Report clinical outcomes of revision ACLR.
- Identify factors contributing to ACLR failure.
Main Methods:
- Retrospective review of surgical logs from four senior knee surgeons (2002-2009).
- Inclusion criteria: primary and revision ACLR on the same knee by the same surgeon.
- Analysis of radiographic studies, operative reports, KT-1000 scores, and chart notes.
Main Results:
- Overall ACLR failure rate was 1.8% (28 of 1944 reconstructions).
- Acute trauma was the cause of failure in 20 cases; technical error in 7; biologic failure in 1.
- Follow-up in 20 patients showed good to excellent outcomes (Lysholm score: 84, IKDC score: 77.2).
Conclusions:
- Traumatic re-injury is the predominant cause of ACLR failure, not surgical or surgeon error.
- Revision ACLR can achieve favorable clinical outcomes.
- Anatomic reconstruction principles and strong fixation contribute to successful ACLR outcomes.