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Methods for assessment of health outcomes in children with burn injury: the Multi-Center Benchmarking Study
Lewis E Kazis1, Austin F Lee, Michelle Hinson
1Department of Health Policy and Management, Boston University School of Public Health, Boston, MA 02118, USA. lek@bu.edu
Insights
The Multi-Center Benchmarking Study (MCBS) established a new model for tracking pediatric burn injury outcomes. This long-term cohort study effectively monitored health and quality of life in young burn patients.
Area of Science:
- Pediatric burn injury research
- Longitudinal cohort studies
- Health outcomes assessment
Background:
- The Multi-Center Benchmarking Study (MCBS) introduced an innovative approach to monitor health outcomes in pediatric burn patients.
- Burn injuries in children and adolescents require specialized, long-term monitoring.
Purpose of the Study:
- To present the methodologies of a multicenter long-term cohort study tracking 1,140 children and adolescents with burn injuries.
- To detail patient-centered health assessments, clinical data collection, and validated questionnaire use.
Main Methods:
- A multicenter long-term cohort study design involving 1,140 pediatric burn patients followed for up to 4 years.
- Utilized the Burn Outcomes Questionnaire (BOQ) and Short-Form Psychosocial Questionnaire for patient-centered data.
- Employed mixed models and generalized estimating equations for analyzing complex, repeated-measures data.
Main Results:
- Achieved high accrual rates (93%) and substantial follow-up completion (65%).
- Presented recovery curves for key BOQ domains (upper extremity function, patient compliance, parental concern) in children aged 5-18.
- Demonstrated the BOQ's sensitivity and responsiveness in capturing changes in recovery over time.
Conclusions:
- The MCBS methodology provides a robust model for multicenter studies on pediatric burn survivors.
- This approach is effective for tracking clinical status and quality of life in children with burn injuries.
- The study highlights the importance of long-term follow-up and patient-centered outcome measures.
Background:
The Multi-Center Benchmarking Study (MCBS) is an innovative program giving a new paradigm for monitoring health outcomes in children and adolescents with burn injuries.
Methods:
This article presents the methodologies for conducting a multicenter long-term cohort study of 1,140 children and adolescents with small to large burn injuries followed from the acute burn discharge at four burn centers for up to 4 years. The components for this project include a broad and rich range of patient-centered health assessments tailored to children with burn injury, an infrastructure for obtaining relevant clinical data, and patient-centered questionnaire data based on validated Shriners Hospitals for Children/American Burn Association Burn Outcomes Questionnaire (BOQ) and Short-Form Psychosocial Questionnaire, aged 0 years to 18 years. Recovery curves are described for analysis of complex data with repeated measures that are based on mixed models and generalized estimating equations, with adjustments for clinical characteristics.
Results:
Accrual rates are as high as 93%, and follow-up rates of completion are 65%. Recovery curves for selected BOQ domains (upper extremity function, patient compliance, and parental concern) are presented for those children and adolescents aged 5 years to 18 years using the rich cohort of data from the MCBS. Results suggest that the BOQ is sensitive and responsive to capturing differences in the rate and levels of change over time.
Conclusion:
The methods implemented in the MCBS are a useful model for conducting large multicenter studies to track the clinical and quality of life of children with burn injuries.
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