Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Profile of Pediatric patients with Foreign Body Aspiration requiring Bronchoscopy in a Tertiary Care Center.

Kathmandu University medical journal (KUMJ)·2026
Same author

Clinical Impact of Next-Generation Sequencing-Guided Targeted Therapies in Advanced Cancer: A Systematic Review and Meta-Analysis.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Social Stigma and Vulnerabilities of Women Living with HIV/AIDS in Kyrgyzstan: Service Providers' Perspectives.

Families in society : the journal of contemporary human services·2025
Same author

A qualitative study of adaptation challenges of Ukrainian refugees in the United States.

Children and youth services review·2025
Same author

Risk and Protective Factors for Well-being and Barriers to Help-Seeking Among Arab-Speaking MENA Immigrants and Refugees in North America: A Scoping Review.

Global social welfare : research, policy & practice·2025
Same author

Hypochlorite Accident in a Pediatric Patient.

Kathmandu University medical journal (KUMJ)·2024

Related Experiment Video

Updated: May 19, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Thyroid dysfunction and its effect in serum lipids.

N Shrestha1

  • 1National College for Advanced Learning, Kathmandu, Nepal. neha_shrestha8@hotmail.com

Journal of Nepal Health Research Council
|August 30, 2012
PubMed
Summary

Thyroid dysfunction significantly impacts lipid profiles, with hypothyroidism leading to elevated total cholesterol and LDL-cholesterol. Monitoring lipid levels in patients with thyroid dysfunction is crucial for cardiovascular disease prevention.

Area of Science:

  • Endocrinology
  • Metabolic Health
  • Clinical Biochemistry

Background:

  • Thyroid hormones regulate lipid and lipoprotein metabolism.
  • Thyroid dysfunctions, such as hypothyroidism and hyperthyroidism, significantly alter lipid levels.
  • Understanding these alterations is key to managing associated health risks.

Purpose of the Study:

  • To determine the prevalence of thyroid dysfunction.
  • To investigate the relationship between hypothyroidism and hyperthyroidism and their impact on lipid profiles.
  • To assess the association between thyroid status and lipid parameters.

Main Methods:

  • A study group of 567 patients was analyzed.
  • A control group of 100 healthy subjects with normal thyroid profiles was included.

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Related Experiment Videos

Last Updated: May 19, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

  • Serum levels of fT3, fT4, TSH, Total Cholesterol, LDL-C, HDL-C, and Triglycerides were measured.

    • Main Results:

    • Thyroid dysfunction was identified in 25.75% of the patients (146 out of 567).
    • Hypothyroidism was significantly associated with elevated Total Cholesterol and LDL-cholesterol.
    • No significant associations were found between lipid levels and hyperthyroidism compared to the control group.

    Conclusions:

    • Hypothyroid patients exhibit significantly altered lipid profiles, characterized by increased Total Cholesterol and LDL-cholesterol.
    • The findings highlight the importance of monitoring lipid profiles in individuals with thyroid dysfunction.
    • Proactive management of lipid levels in thyroid dysfunction can mitigate the risk of cardiovascular diseases.