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Updated: May 19, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
The prevalence of metal-based drugs as therapeutic or diagnostic agents: beyond platinum
Declan Gaynor1, Darren M Griffith
1Department of Basic Medical Sciences, Royal College of Surgeons in Ireland Medical University of Bahrain, Building No. 2441, Road 2835, Busaiteen 228, PO Box 15503, Adliya, Kingdom of Bahrain. dgaynor@rcsi-mub.com
Abstract:
Metal complexes and metal salts have a wide range of medicinal applications and are extensively administered to patients or purchased over the counter as a matter of routine. The abundance and variety of non-platinum metal complexes, which are approved for use as therapeutic or diagnostic agents, are highlighted. Current insights into the mechanism of action or indeed lack thereof of a selection of metallodrugs are discussed. Ultimately this perspective seeks to inspire chemists to tackle new challenges and raise awareness of opportunities in the area of inorganic therapeutic and diagnostic medicine.
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