Insights into bone marrow-derived mesenchymal stem cells safety for cutaneous repair and regeneration

Wound healing involves the orchestration of a complex process of interactions between numerous types of cell, components of extracellular matrix and signalling molecules following injury, which is usually a highly successful biological course to reconstruct the integrity of the skin. Nevertheless, when skin is severely damaged, the injured skin is limited in its ability to repair itself and possibly results in the hypertrophic scars or so-called keloids, and non healing wound or ulcer. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are being clinically explored as a promising therapy in the field of tissue repair and regeneration. However, potential risks associated with these cell-based therapies remain uncertain. The aim of this review is to summarise the safety issues accompanying the administration of BM-MSCs for acute or chronic skin repair and regeneration. More importantly, this review highlights the requirement for fundamental research to improve future clinical application of these strategies, as well as for regulatory authorities to establish clinical criteria to identify the qualitative requirements for the manufacture process of cells products, which will ensure the manufacture process of the best benefit-to-risk ratio of cell-based therapy for the patients.