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Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

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Updated: May 19, 2026

An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Thyroid hormone and obesity.

Elizabeth N Pearce1

  • 1Boston University School of Medicine, Boston, Massachusetts 02118, USA. elizabeth.pearce@bmc.org

Current Opinion in Endocrinology, Diabetes, and Obesity
|August 31, 2012
PubMed
Summary
This summary is machine-generated.

Thyroid treatment can cause modest weight loss, primarily water. Thyroid status and body weight are complexly linked, with obesity affecting thyroid hormones, but thyroid hormone treatment doesn't consistently aid weight loss in obese individuals.

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Area of Science:

  • Endocrinology
  • Metabolism
  • Clinical Medicine

Background:

  • Thyroid hormones play a crucial role in regulating metabolism and body weight.
  • Understanding the bidirectional relationship between thyroid function and body mass is essential for clinical practice.

Purpose of the Study:

  • To review recent clinical studies on thyroid treatment effects on weight.
  • To examine associations between thyroid status and weight.
  • To investigate the impact of obesity and weight changes on thyroid function.

Main Methods:

  • Literature review of recent clinical studies.
  • Analysis of associations between thyroid-stimulating hormone (TSH), T3, and body weight/BMI.
  • Evaluation of thyroid hormone treatment effects on weight in hypothyroid and obese individuals.

Main Results:

  • Treatment for hypothyroidism leads to weight loss, mainly water weight, not fat.
  • Conflicting evidence exists regarding thyroidectomy's effect on weight.
  • A positive association is observed between TSH levels and body weight/BMI in euthyroid individuals.
  • Obesity is associated with increased TSH and T3, potentially mediated by leptin.
  • Thyroid hormone treatment does not consistently induce weight loss in obese euthyroid individuals.

Conclusions:

  • The relationship between body weight and thyroid status is intricate.
  • Current evidence does not support thyroid hormone treatment for weight loss in obese euthyroid individuals.
  • Thyroid hormone analogues show potential for future weight loss interventions.