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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: May 19, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Targeted therapy for lung cancer.

Frunze Petrosyan¹, Hamed Daw, Abdo Haddad

¹Fairview Hospital, A Cleveland Clinic Hospital, Cleveland, Ohio, USA.

Anti-Cancer Drugs

|August 31, 2012

Summary

Personalized treatments targeting specific mutations in non-small-cell lung cancer (NSCLC) are improving outcomes. Ongoing research in tyrosine kinase inhibitors and detection methods promises more affordable and effective lung cancer care.

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Last Updated: May 19, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Area of Science:

Oncology
Molecular Biology
Pharmacology

Background:

Lung cancer remains a leading cause of cancer-related mortality worldwide.
Advances in molecular diagnostics have identified specific genetic alterations driving non-small-cell lung cancer (NSCLC).
Targeted therapies based on these alterations are transforming treatment strategies.

Purpose of the Study:

To review the current landscape of personalized medicine in non-small-cell lung cancer (NSCLC).
To highlight the impact of targeted therapies like erlotinib and crizotinib.
To discuss emerging trends in NSCLC treatment and detection.

Main Methods:

Review of recent clinical observations and research findings in NSCLC.
Analysis of the efficacy and safety of targeted therapies.
Examination of ongoing research into resistance mechanisms and novel detection systems.

Main Results:

Activating mutations in epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) positivity enable personalized NSCLC treatment.
Erlotinib and crizotinib demonstrate efficacy and safety in specific patient subgroups.
Personalized treatment for nonsquamous NSCLC is advancing with new tyrosine kinase inhibitors and detection methods.

Conclusions:

Personalized treatment strategies are making NSCLC care more effective and practical.
Continued research into targeted therapies and resistance mechanisms is crucial.
National Comprehensive Cancer Network guidelines now incorporate these advancements for advanced nonsquamous NSCLC.