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[Primary cutaneous lymphoma: experience with 10 cases].

C Franco1, I Sazunić, V Martínez

  • 1Servicio de Anatomía Patológica, Hospital San Juan de Dios, Santiago de Chile.

Revista Medica De Chile
|May 1, 1990
PubMed
Summary
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This study examines 10 patients with T-cell cutaneous lymphoma, detailing their clinical progression and histopathology. Findings highlight varied outcomes, including evolution to Mycosis fungoides and progression to fatal Immunoblastic lymphoma.

Area of Science:

  • Dermatology
  • Oncology
  • Immunology

Context:

  • Cutaneous lymphomas represent a diverse group of T-cell malignancies affecting the skin.
  • Understanding the clinical behavior and histopathologic features is crucial for diagnosis and prognosis.

Purpose:

  • To present clinical findings, staging, histopathology, and human T-lymphotropic virus (HTLV) antibody screening results in 10 patients with cutaneous T-cell lymphoma.
  • To describe the disease course and outcomes for different subtypes, including Lymphomatoid papulosis, Mycosis fungoides, and peripheral T-cell lymphoma.

Summary:

  • All 10 patients exhibited a T-cell immunotype.
  • Three patients had Lymphomatoid papulosis, with one progressing to Mycosis fungoides and another to Immunoblastic lymphoma.
  • Two patients had Mycosis fungoides, and five had peripheral T-cell lymphoma, two of whom experienced rapid progression and death.

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Impact:

  • This case series provides insights into the heterogeneous presentation and clinical trajectories of cutaneous T-cell lymphomas.
  • Highlights the importance of accurate histopathologic classification and monitoring for disease progression.
  • Contributes to the understanding of T-cell lymphoma subtypes and their associated outcomes.