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New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment

Viktor Umansky1

  • 1Skin Cancer Unit; German Cancer Research Center; and, University Hospital Mannheim; Heidelberg, Germany.

Oncoimmunology
|August 31, 2012
PubMed

Using ret transgenic mouse model of spontaneous melanoma, we showed an accumulation of melanoma antigen-specific memory T cells. However, their antitumor effects could be blocked by myeloid-derived suppressor cells, tolerogenic dendritic cells and regulatory T cells. We suggest that effective melanoma immunotherapy should include the neutralization of immunosuppressive tumor microenvironment.

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