Effect of CpG ODN on monocytic myeloid derived suppressor cells
Hidekazu Shirota1, Dennis M Klinman
1Cancer and Inflammation Program; National Cancer Institute; Frederick, MD USA ; Basic Science Program; SAIC-Frederick, Inc.; Frederick, MD USA.
Oncoimmunology
|August 31, 2012
Abstract:
CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8(+) T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression.
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