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Association between chronic kidney disease and urinary calculus by stone location: a population-based study
Joseph J Keller1, Yi-Kuang Chen, Herng-Ching Lin
1School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University, Taipei, Taiwan.
BJU International
|September 1, 2012
Summary
Chronic kidney disease (CKD) is associated with urinary calculus (UC), including kidney, ureter, and bladder stones. This study confirms a link between CKD and UC across all stone locations.
Area of Science:
- Nephrology
- Urology
- Epidemiology
Background:
- Previous studies explored the link between kidney stones and chronic kidney disease (CKD).
- Research has not extensively investigated the association between CKD and urinary calculus (UC) in other parts of the urinary system.
- This study addresses the gap by examining CKD in relation to kidney, ureter, and bladder stones.
Purpose of the Study:
- To investigate the association between chronic kidney disease (CKD) and prior diagnoses of kidney, ureter, and bladder calculus.
- Utilize a population-based dataset from Taiwan to explore these associations.
- Expand on existing research by considering all locations of urinary calculus in relation to CKD.
Main Methods:
- A cohort design was employed, identifying 21,474 patients with a first-time diagnosis of CKD between 2001 and 2009.
- 21,474 control subjects were frequency-matched by sex, age group, and index year.
- Conditional logistic regression analyses were used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the association between CKD and prior UC diagnoses.
Main Results:
- Patients with CKD showed a significantly higher likelihood of a prior UC diagnosis (OR 1.91, 95% CI 1.81-2.01).
- Specifically, CKD patients were more likely to have had kidney calculus (OR 2.10), ureter calculus (OR 1.68), bladder calculus (OR 1.49), and unspecified UC (OR 1.89).
- All calculated ORs indicated a statistically significant association between CKD and UC, regardless of stone location.
Conclusions:
- A significant association exists between chronic kidney disease (CKD) and urinary calculus (UC).
- This association is consistent across all investigated locations of urinary calculus, including kidney, ureter, and bladder.
- The findings underscore the importance of considering urinary calculus as a potential factor in the context of CKD.
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