Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transfusion-associated graft-versus-host disease.

J M Rappeport1

  • 1Yale University School of Medicine, New Haven, Connecticut.

The Yale Journal of Biology and Medicine
|September 1, 1990
PubMed
Summary

Graft-versus-host disease (GVHD) occurs when donor lymphocytes attack recipient antigens after transplantation. This immune response can happen after bone marrow transplants, blood transfusions, or organ transplants, even in immunocompetent patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Handicapping outcome.

Critical care medicine·2000
Same author

Cyclophosphamide, cytosine arabinoside and TBI as a conditioning regimen for allogeneic bone marrow transplantation in patients with leukemia.

Bone marrow transplantation·1999
Same author

13-cis-retinoic acid-induced eosinophilia following autologous bone marrow transplantation for neuroblastoma.

Medical and pediatric oncology·1999
Same author

Aspergillus antigen detection in the diagnosis of invasive aspergillosis.

The Journal of infectious diseases·1995
Same author

B-cell precursor bone marrow reconstitution after bone marrow transplantation.

American journal of clinical pathology·1994
Same author

Pharmacology of agents used in bone marrow transplant conditioning regimens.

Critical reviews in oncology/hematology·1992

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Hematology

Background:

  • Graft-versus-host disease (GVHD) is a significant complication following allogeneic transplantation.
  • It arises from donor T-lymphocytes recognizing recipient antigens as foreign.
  • GVHD can also occur in non-transplant settings involving lymphocyte engraftment.

Purpose of the Study:

  • To describe the clinical and pathological features of graft-versus-host disease.
  • To outline the various scenarios leading to GVHD beyond bone marrow transplantation.
  • To highlight the immunological basis of GVHD in different clinical contexts.

Main Methods:

  • Review of clinical and pathological data related to GVHD.
  • Analysis of immunological mechanisms underlying GVHD.
  • Identification of risk factors and patient populations susceptible to GVHD.

Main Results:

  • GVHD is primarily associated with bone marrow transplantation due to donor lymphocyte recognition of recipient antigens.
  • Lymphocyte engraftment from blood transfusions, transplacental transfer, and solid organ transplants can also induce GVHD.
  • The syndrome can affect both severely immunodeficient recipients and immunocompetent individuals exposed to non-self histocompatibility antigens.

Conclusions:

  • Graft-versus-host disease is a complex immune-mediated disorder with diverse etiologies.
  • Understanding the mechanisms of GVHD is crucial for managing and preventing this complication in various clinical settings.
  • Prevention and treatment strategies must consider the immunological status of the recipient and the source of transfused lymphocytes.

Related Experiment Videos