Invited commentary: the 21st century epidemiologist--a need for different training?

Area of Science:

• Epidemiology
• Pathology
• Molecular Biology

Background:

• The integration of molecular pathological epidemiology (MPE) into research is proposed.
• A potential overemphasis on MPE may overshadow traditional epidemiologic principles and hypothesis-driven research.
• Historically, pathology and advanced technologies have been incorporated into epidemiologic studies.

Purpose of the Study:

• To critically evaluate the role and integration of molecular pathological epidemiology (MPE) within broader epidemiologic research.
• To emphasize the importance of hypothesis-driven research in the context of new molecular techniques.
• To discuss the potential risks of MPE driving research without specific hypotheses or population characteristics.

Main Methods:

• Literature review and critical analysis of the proposed role of MPE.
• Discussion of historical integration of pathology and technology in epidemiology.
• Examination of the potential impact of molecular techniques (metabolomics, genomics, proteomics, microarrays) on study design.

Main Results:

• Epidemiology has a long-standing tradition of incorporating pathology and advanced technologies.
• MPE represents an advancement in molecular techniques applicable to epidemiologic investigations.
• There is a concern that MPE may lead to hypothesis-free research, diminishing the epidemiologist's role.

Conclusions:

• Molecular pathological epidemiology (MPE) offers valuable tools for enhancing epidemiologic studies.
• The integration of MPE should be guided by specific hypotheses and population characteristics.
• Maintaining a hypothesis-driven approach is crucial to prevent molecular techniques from solely dictating research direction.