Related Experiment Video
Updated: May 19, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Granuloma annulare associated with cutaneous marginal zone lymphoma: a case linking a hematologic malignancy with
Karolyn A Wanat1, Rosalie Elenitsas, Ellen J Kim
1Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract:
Granuloma annulare and other granulomatous disorders have been reported to be associated with internal malignancies, primarily T-cell lymphomas, whereas very few reports of granulomatous disorders in association with B-cell lymphoma exist in the literature. We report a case of marginal zone lymphoma, a cutaneous B-cell lymphoma that occurred concomitantly with refractory granuloma annulare. This case highlights the importance of considering both B- and T-cell dyscrasias in the case of refractory or extensive granulomatous lesions and the importance of histopathologic examination in the evaluation of these lesions.
