Related Experiment Video
Updated: May 19, 2026

11:42
Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
Published on: September 12, 2014
Restylane persisting in lower eyelids for 5 years.
Journal of Cosmetic Dermatology
|September 4, 2012
Summary
Delayed eyelid puffiness after hyaluronic acid filler treatment, such as Restylane, can persist for years. This case highlights a rare long-term cosmetic outcome from periorbital injections.
Area of Science:
- Dermatology
- Plastic Surgery
- Ophthalmology
Background:
- Hyaluronic acid fillers are commonly used for periorbital rejuvenation.
- Adverse effects like edema and bruising are typically short-lived.
Observation:
- A 58-year-old woman experienced persistent lower eyelid puffiness for 5 years.
- This symptom began approximately 5 years after receiving Restylane injections in the periorbital area.
Findings:
- The case presents an unusually delayed onset of a negative cosmetic outcome following hyaluronic acid filler treatment.
- Periorbital hyaluronic acid injections can lead to long-lasting adverse effects, including persistent edema.
Implications:
- Clinicians should be aware of the potential for delayed and prolonged adverse effects from hyaluronic acid fillers.
- Patient counseling regarding long-term risks associated with periorbital filler treatments is crucial.
Related Concept Videos
Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
Renewal of Skin Epidermal Stem Cells
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

