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Related Concept Videos

Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...

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Related Experiment Video

Updated: May 19, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

RNA interference as a plausible anticancer therapeutic tool.

Puthucode Venkatakrishnan Ramachandran1, Savarimuthu Ignacimuthu

  • 1Entomology Research Institute, Loyola College, Tamilnadu, India.

Asian Pacific Journal of Cancer Prevention : APJCP
|September 4, 2012
PubMed
Summary

RNA interference (RNAi) offers a breakthrough for gene silencing, showing promise in treating diseases like cancer. This technology targets specific faulty genes, potentially leading to more precise and effective cancer therapies than traditional methods.

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Area of Science:

  • Biotechnology
  • Genetics
  • Oncology

Background:

  • Cancer arises from genetic mutations and epigenetic changes affecting gene expression and DNA.
  • Current cancer therapies, like chemotherapy, often harm healthy cells alongside cancerous ones.
  • RNA interference (RNAi) presents a novel approach for targeted gene silencing.

Purpose of the Study:

  • To review the successful application of RNAi inducers against various cancer types.
  • To highlight RNAi's potential as a specific therapeutic agent for cancer treatment.

Main Methods:

  • Review of existing literature on RNA interference in cancer therapy.
  • Analysis of studies demonstrating the efficacy of RNAi inducers.

Main Results:

  • RNAi technology enables the deactivation of specific molecular targets, such as mutant genes.
  • Successful use of RNAi inducers has been demonstrated across different forms of cancer.

Conclusions:

  • RNA interference holds significant potential for developing targeted cancer medicines.
  • RNAi-based therapies offer a more precise alternative to conventional cancer treatments.