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Updated: May 19, 2026
Pseudomonas aeruginosa Induced Lung Injury Model
Published on: October 29, 2014
An experimental model for induction of lung cancer in rats by Chlamydia pneumoniae
De-Jie Chu1, Shui-Gen Guo, Chun-Feng Pan
1Department of Pulmonary Medicine, Jinshan Hospital, Fudan University, Shanghai, China. dejiechu@yeah.net
Objective:
To assess induction effects of Chlamydia pneumoniae (Cpn) on lung cancer in rats.
Methods:
A lung cancer animal model was developed through repeated intratracheal injection of Cpn (TW-183) into the lungs of rats, with or without exposure to benzo(a)pyrene (Bp). Cpn antibodies (Cpn-IgA, -IgG, and -IgM) in serum were measured by microimmunofluorescence. Cpn-DNA or Cpn-Ag of rat lung cancer was detected through polymerase chain reaction or enzyme-linked immunosorbent assay.
Results:
The prevalence of Cpn infection was 72.9% (35/48) in the Cpn group and 76.7% (33/43) in the Cpn plus benzo(a)pyrene (Bp) group, with incidences of lung carcinomas in the two groups of 14.6% (7/48) and 44.2% (19/43), respectively (P-values 0.001 and <0.001 compared with normal controls).
Conclusions:
A rat model of lung carcinoma induced by Cpn infection was successfully established in the laboratory for future studies on the treatment, prevention, and mechanisms of the disease.
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