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Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...

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Updated: May 19, 2026

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
07:53

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

Exercise in neuromuscular diseases.

R Ted Abresch1, Gregory T Carter, Jay J Han

  • 1Department of Rehabilitation Medicine, University of California, Davis, 4860 Y Street Suite, 3850, Sacramento, CA 95817, USA. rtabresch@ucdavis.edu

Physical Medicine and Rehabilitation Clinics of North America
|September 4, 2012
PubMed
Summary
This summary is machine-generated.

Evidence for exercise benefits in neuromuscular diseases (NMDs) is limited, necessitating robust clinical trials. Future research should focus on functional status and quality of life outcomes for effective exercise prescriptions.

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A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

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Last Updated: May 19, 2026

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
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Published on: September 13, 2015

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Published on: January 29, 2016

Area of Science:

  • Neurology
  • Exercise Science
  • Rehabilitation Medicine

Background:

  • Neuromuscular diseases (NMDs) encompass a range of debilitating conditions affecting muscle and nerve function.
  • The role of exercise in managing NMDs is not well-defined due to limited evidence.
  • Current knowledge on exercise benefits and contraindications for NMD patients is insufficient.

Purpose of the Study:

  • To review the existing literature on the benefits and contraindications of exercise for individuals with NMDs.
  • To highlight the limitations in the current evidence base for exercise prescriptions in NMDs.
  • To propose a framework for future research to establish effective exercise guidelines.

Main Methods:

  • Literature review of current knowledge on exercise and NMDs.
  • Analysis of the evidence base for exercise prescriptions.
  • Identification of research gaps and recommendations for future studies.

Main Results:

  • Specific, evidence-based exercise prescriptions for NMDs are currently lacking.
  • The existing evidence base is insufficient to guide exercise recommendations.
  • Multicenter, randomized controlled trials with adequate power and validated outcome measures are needed.

Conclusions:

  • Further research, including large-scale, multicenter trials, is crucial to understand exercise effects in NMDs.
  • Outcome measures should extend beyond traditional efficacy metrics to include functional status and health-related quality of life.
  • Establishing reliable exercise guidelines requires significant research investment across various NMDs.