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Does phase angle correlate with hyperhomocysteinemia? A study of patients with classical homocystinuria

Soraia Poloni1, Ingrid D Schweigert Perry, Vânia D'Almeida

  • 1Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Brazil.

Clinical Nutrition (Edinburgh, Scotland)
|September 4, 2012
PubMed

Insights

Phase angle may indicate cellular integrity in classical homocystinuria. This study found significant correlations between phase angle and homocysteine, methionine, and cysteine levels in patients with this rare genetic disease.

Area of Science:

  • Biochemistry
  • Medical Diagnostics
  • Genetics

Background:

  • Classical homocystinuria is a rare genetic disorder causing severe hyperhomocysteinemia, elevated methionine, and reduced cysteine.
  • The diagnostic and prognostic value of phase angle in hyperhomocysteinemia remains unassessed.

Purpose of the Study:

  • To investigate the relationship between phase angle and homocysteine, cysteine, and methionine levels in classical homocystinuria patients.
  • To explore phase angle as a potential indicator of cellular integrity and disease prognosis in classical homocystinuria.

Main Methods:

  • Eight patients with classical homocystinuria were studied.
  • Phase angle was measured using a tetrapolar bioimpedance analyzer.
  • Serum homocysteine, cysteine, and methionine levels were quantified via High-Performance Liquid Chromatography (HPLC).

Main Results:

  • A significant negative correlation was observed between phase angle and homocysteine (r = -0.807, p = 0.015) and methionine (r = -0.711, p = 0.048) levels.
  • A significant positive correlation was found between phase angle and cysteine levels (r = 0.836, p = 0.010).
  • Phase angle also correlated positively with Body Mass Index (BMI) and arm muscle circumference (p < 0.05).

Conclusions:

  • Phase angle may serve as a valuable indicator of cellular integrity and prognosis in classical homocystinuria.
  • Findings suggest a potential role for phase angle in monitoring other forms of hyperhomocysteinemia and inborn errors of metabolism.

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