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Related Concept Videos

Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

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Nucleotide Excision Repair01:08

Nucleotide Excision Repair

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Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

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Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

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Related Experiment Video

Updated: May 19, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

RECQL4 in genomic instability and aging.

Deborah L Croteau1, Dharmendra Kumar Singh, Leslie Hoh Ferrarelli

  • 1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard Suite 100, Baltimore, MD 21040, USA.

Trends in Genetics : TIG
|September 4, 2012
PubMed
Summary
This summary is machine-generated.

RecQ helicase-like 4 (RECQL4) is a key protein involved in DNA repair and genomic stability. Recent research highlights its role in aging and potential links to disease, despite its previously understudied nature.

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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
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Published on: September 29, 2011

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
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Published on: August 23, 2024

Area of Science:

  • Genetics
  • Molecular Biology
  • Biochemistry

Background:

  • Helicases unwind DNA, crucial for replication, repair, and transcription.
  • The RecQ helicase family, known as "guardians of the genome," includes five human proteins.
  • RECQL4, unlike WRN and BLM, has been less studied but is increasingly recognized for its roles.

Purpose of the Study:

  • To summarize recent findings on RECQL4.
  • To elucidate RECQL4's functions in DNA metabolism and aging.

Main Methods:

  • Review of recent scientific literature on RECQL4.
  • Analysis of RECQL4's known helicase activity and cellular localization.

Main Results:

  • RECQL4 exhibits helicase activity.
  • RECQL4 localizes to telomeres and mitochondria.
  • Emerging protein interactions suggest novel roles for RECQL4.

Conclusions:

  • RECQL4 is implicated in maintaining genomic stability.
  • RECQL4's functions connect DNA integrity with aging processes.
  • Further investigation into RECQL4 is warranted due to its disease and aging implications.