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Related Concept Videos

Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Markings01:26

Bone Markings

Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
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Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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Updated: May 19, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Bone marrow lesions are associated with altered trabecular morphometry.

J B Driban1, A Tassinari, G H Lo

  • 1Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA. jdriban@tuftsmedicalcenter.org

Osteoarthritis and Cartilage
|September 4, 2012
PubMed
Summary
This summary is machine-generated.

Bone marrow lesions (BMLs) in osteoarthritis patients show increased bone volume fraction, number, and thickness, with decreased spacing. These findings in knee osteoarthritis suggest localized bone remodeling or compression.

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Area of Science:

  • Orthopedics and Sports Medicine
  • Radiology and Medical Imaging
  • Biomedical Engineering

Background:

  • Bone marrow lesions (BMLs) are common in osteoarthritis (OA) but their pathological basis is unclear.
  • In vivo evaluation of trabecular structure associated with BMLs is lacking.

Purpose of the Study:

  • To evaluate the in vivo trabecular bone structure in relation to the presence and size of BMLs.
  • To use quantitative magnetic resonance (MR)-based trabecular morphometry for this evaluation.

Main Methods:

  • 158 Osteoarthritis Initiative (OAI) participants underwent 3T MR knee imaging.
  • Quantitative MR trabecular morphometry (bone volume fraction, number, spacing, thickness) was performed on proximal medial tibial subchondral bone.
  • BMLs were assessed in adjacent subchondral bone and classified as none, small, or large.

Main Results:

  • Knees with small or large BMLs exhibited significantly higher apparent bone volume fraction (P < 0.01).
  • Increased trabecular number (P < 0.01) and thickness (P = 0.02) were observed in knees with BMLs.
  • A statistically significant decrease in trabecular spacing (P < 0.01) was found in the presence of BMLs.

Conclusions:

  • BMLs in knee OA are associated with altered subchondral trabecular structure.
  • Findings indicate higher bone density and altered trabecular architecture in areas with BMLs.
  • These structural changes may reflect localized bone remodeling or compressive forces.